Mala D is a government owned, daily oral hormonal contraceptive pill used to prevent pregnancy. It is available in a pack of 28 tablets. It does not allow pregnancy by preventing ovulation, implantation and making cervical secretions thick. Mala D is supposed to be hundred percent effective when taken correctly.
Here is given more about this medicine, such as benefits, indication/therapeutic uses, composition and dosage.
Brand: Hindustan Latex Limited
Category: Hormonal Combined Contraceptive
Contains: Progestin and estrogen along
Pack: 28 tabs = 21 tabs for contraception + 7 tabs of ferrous fumerate for iron supplementation
Price: Rs 3/- for a cycle
Ingredients of Mala-D
Mala-D Combination hormonal contraceptive pills:
Each film coated white colored tablet contains
- Levonorgestrel 0.15 mg
- Ethinyl estradiol 0.03mg.
Levonorgestrel is synthetic progestogen with chemical formula 18, 19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl- 17-hydroxy-, (17α)-, (-)-,. Ethinyl estradiol is synthetic estrogen with chemical formula 19-Norpregna-1,3, 5(10)-trien-20-yne-3, 17-diol, (17α)-.
The combination of progestogen and estrogen suppress gonadotropins. It inhibits ovulation, makes changes in cervical mucus and endometrium.
Each brown colored film coated tablet contains
Ferrous fumerate 60mg equivalent to ferrous iron 19.5mg
Mechanism of Action
- It is a combined hormonal contraceptive.
- It inhibits ovulation.
- It produce alterations in the genital tract, including changes in the cervical mucus, rendering it unfavorable for sperm penetration.
- It changes the endometrium producing an unfavorable environment for fertilization.
Advantages of Mala-D
- It is highly effective for pregnancy prevention.
- It decreases menstrual flow and cramps.
- It regulates menstrual cycles.
- It protects against ovarian and endometrial cancer.
- It decreases benign breast lumps.
Disadvantages of Mala-D
- It contains progestogen. Some progestogens may elevate LDL levels and may render the control of hyperlipidemias more difficult.
- Woman suffering from lipoprotein metabolism taking estrogen-containing preparations, are at risk of significant elevations of plasma triglycerides leading to pancreatitis.
- It may cause some degree of fluid retention, Nausea and dizziness, Breast tenderness, Intermittent bleeding, Headaches and Weight gain.
- It may decrease glucose tolerance.
- It may decrease quantity and quality of breast milk.
- Important Therapeutic Uses of Mala-D
- It is used to prevent pregnancy.
Dosage of Mala-D
On first day of menstrual cycle, take 1 tablet daily for 21 consecutive days.
Then for 7 days take Iron and folic acid tabs.
- Thrombophlebitis or thromboembolic disorders, past history of deep vein thrombophlebitis or thromboembolic disorders
- Cerebrovascular or coronary artery disease (current or history)
- Valvular heart disease with thrombogenic complications
- Uncontrolled hypertension
- Diabetes with vascular involvement
- Headaches with focal neurological symptoms
- Major surgery with prolonged immobilization
- Known or suspected carcinoma of the breast or personal history of breast cancer
- Hepatic adenomas or carcinomas, or active liver disease
- Carcinoma of the endometrium or other known or suspected estrogen-dependent neoplasia
- Undiagnosed abnormal genital bleeding
- Cholestatic jaundice of pregnancy or jaundice with prior pill use
- Known or suspected pregnancy
- Breast feeding
An increased risk of the following serious adverse reactions has been associated with the use of
- Arterial thromboembolism
- Pulmonary embolism
- Myocardial infarction
- Cerebral hemorrhage
- Cerebral thrombosis
- Gallbladder disease
- Hepatic adenomas or benign liver tumor
- There is evidence of an association between the following conditions and the use of oral contraceptives:
- Mesenteric thrombosis
- Retinal thrombosis
- The following adverse reactions have been reported in patients receiving oral contraceptives.
- Gastrointestinal symptoms (such as abdominal cramps and bloating)
- Breakthrough bleeding
- Change in menstrual flow
- Temporary infertility after discontinuation of treatment
- Edema/fluid retention
- Melasma/chloasma which may persist
- Changes in Breast, tenderness, enlargement, and secretion
- Change in weight or appetite (increase or decrease)
- Change in cervical ectropion and secretion
- Possible diminution in lactation when given immediately postpartum
- Cholestatic jaundice
- Migraine headache
- Rash (allergic)
- Mood changes, including depression
- Vaginitis, including candidiasis
- Intolerance to contact lenses
- Decrease in serum folate levels
- Exacerbation of porphyria
- Exacerbation of chorea
- Aggravation of varicose veins
- Anaphylactic/anaphylactoid reactions, including urticaria, angioedema, and severe reactions with respiratory and circulatory symptoms
- There may be some delay in becoming pregnant after stopping oral contraceptives. It may be
- Advisable There does not appear to be any increase in birth defects in newborn babies when pregnancy occurs soon after stopping the pill.