Rutin (3, 3′, 4′, 5, 7-pentahydroxyflavone-3-rhamnoglucoside) is bright yellow or greenish-yellow substance with Molecular Formula C27H30O16. Rutin is also called vitamin P (bioactive flavonoid are referred as vitamin P).
The name ‘Rutin’ came from a plant known as Ruta graveolens that also contains rutin. It is a flavonol glycoside comprised of quercetin and rutinose found in many plants, including BUCKWHEAT seeds. Buckwheat seeds are the richest source of rutin.
Rutin has a wide range of pharmacological properties. It has antidiabetic, anti-inflammatory, antioxidant, β-amyloid oligomer-reducing, antimicrobial, antifungal, neuroprotective and anti-allergic activities. It has been used therapeutically to decrease capillary fragility. It shows beneficial effects in various chronic diseases, such as cancer, diabetes, hypertension, hypercholesterolemia, neurodegenerative diseases and Alzheimer’s disease. Scientist are still not able to give detail of mechanism, by which Rutin work in body.
Rutin is obtained from various plants. Buckwheat is excellent source of Rutin, Other plants which contain Rutin are Tobacco, Forsythia, Sophora Japonica, Tomato, Flavedo, Hydrangea, Viola, Asparagus, Red Pepper, Apples, Cherries, Aronia Berries and Citrus Fruits. Rutin is also present in inflorescence and leaves of many herbs such as rue, rosemary, Dandelion or sage, and black and green tea.
Rutin extracts are available in the market as dietary supplement. There are approximately 130 registered therapeutic medicinal preparations are containing rutin.
Rutin (Quercetin-3-Rutinoside) General Information
- Synonym: Rutoside, Quercetin-3-O-Rutinoside Or Sophorin
- Rutin content derived from buckwheat seeds: 0.48mg/100g to 4.97mg/100g
- Chemistry: Glycoside between the flavonol quercetin and the disaccharide rutinose (α-LRhamnopyranosyl-(1→6)-β-D-glucopyranose)
- Molecular Formula: C27H30O16
- Molecular weight: 610.5175 g/mol
- Melting point: 195 °C
- Boiling point: 983.1 °C at 760 mmHg
Medicinal Properties of Rutin
Rutin is bioflavonoid and vitamin. It is used in prevention and treatment of variety of diseases including piles, hemorrhage, heart diseases, varicose veins, bruises on skin, allergy etc. Below is given important medicinal properties of Rutin.
- Anti-oxidant: decrease oxidative stress and thus preserve the structural and functional integrity of cells.
- Antibacterial: Active against bacteria
- Antidiabetic: Stabilize and control blood glucose levels.
- Anti-inflammatory: Reducing inflammation by acting on body mechanisms.
- Anti-tumor: Preventing or inhibiting the formation or growth of tumors
- Antifungal: Limits or prevents the growth of yeasts and other fungal organisms
- Anti-allergic: Inhibit the production and release of histamine from immune cells known as mast cells and basophiles and calm the inflammatory response.
- Anticoagulant: inhibiting the coagulation (fluid to thickened mass) of the blood.
- Antiulcer: Tending to prevent or heal ulcers.
- Antithrombotic: Reduces the formation of blood clots (thrombi).
- β-amyloid oligomer-reducing: Inhibits g pathologic agents in Alzheimer’s disease.
- Neuroprotective: Protecting nervous system, its cells, structure and function.
Dosage of Rutin 500 mg Tablets
Rutin 500 mg Tablets dietary supplement, is taken in dose of 1 capsule, once or twice daily with water after meal.
Indication / Therapeutic Uses of Rutin 500 mg Tablets
Rutin is a strong antioxidant and prevents cells from free radical damage. It is excellent for circulatory system and promotes healthy circulation. Rutin 500 mg Tablets supports vascular strength. Rutin is found to inhibit thrombus formation. The Food and Drug Administration (FDA) has established that Rutin is safe and, thus provides a safe and inexpensive drug that could reduce recurrent clots.
- Rutin helps in many conditions. Some of them are given below:
- Bruises, spider veins, and varicose veins
- Chronic ulcerative colitis
- Cardiovascular problems
- Chronic cerebral hypoperfusion (reduction in cerebral blood flow), memory loss
- Diabetes, diabetes related problems
- Prevention and treatment of heart attacks and stroke
- Prevention and treatment of deep vein thrombosis and pulmonary embolism
- Prevention of oxidative damage, as antioxidant
- Piles, hemorrhoids (swollen veins in the anus and rectum), after hemorrhoidectomy
- Prevention and treatment of eye diseases such as macular degeneration, cataracts, and glaucoma
- Inflammation Inhibit thrombosis / blood clot (formation of solid massor thrombus in circulation from the constituents of flowing blood), inhibits both platelet accumulation and fibrin generation during thrombus formation
Rutin Contraindications, Interactions, Side-effects
- Multiple human clinical trials with rutin have shown that it is well tolerated and safe.
- Rutin exerts anti-thrombotic activity and may reduce effect of anti-coagulant medicines.
- Rutin supplements can cause miscarriage so should not be used during pregnancy. It may have teratogenic (halt the pregnancy or produce a congenital malformation / birth defect) effect.
- Its use should be avoided during breast feeding period.
- Allergic reactions are rare. But skin rashes, facial swelling and breathing problems can occur sometimes. Other indicated possible side effects include headache, dizziness, diarrhea, fatigue, upset stomach, or hair loss and allergic reactions.