Alzheimer’s and Ayurveda – Useful Herbs and Medicine

Ayurvedic, Complementary and alternative medicines for older with Alzheimer’s disease. Ayurvedic medicines for dementia and how to cure alzheimer disease naturally. Know patanjali products for alzheimer's and alzheimer disease treatment guidelines.

Alzheimer’s disease (AD) is a brain disorder associated with the progressively worsening of cognitive functions and behavioral disturbances. It results in associated with mental and physical disability. It causes memory disturbances, spatial and temporal disorientation, and getting lost in familiar surroundings. As the disease progresses, aphasia, apraxia, acalculia, and sleepwalking may develop.  The Alzheimer’s patient may forget his own family members with passage of time.

The actual reason for Alzheimer’s disease is not known. It is a neurodegenerative disease in which the nerve cells in the memory region of the brain are greatly reduced.  Alzheimer’s is a progressive disease. It ultimately results in irreversible debilitating cognitive impairment in patients. Alzheimer’s is the most common cause of dementia among older adults.

Dementia is the loss of cognitive functioning—thinking, remembering, and reasoning—and behavioral abilities to such an extent that it interferes with a person’s daily life and activities. Memory problems are typically one of the first signs of cognitive impairment related to Alzheimer’s disease.

Although in modern medicine some medications appear to produce transient improvement, there is no medication available that can halt the progression of disease.

Though there is no precise equivalent for Alzheimer’s in Ayurveda but it can be related to cognitive dysfunction with the aging process. The condition can be helped with nootropic and antioxidant medicinal herbs. It is considered a Vata Dosha. So, the Vata reducing diet is especially beneficial. Intake of adaptogenic, immunomodulatory, and antioxidant Ayurvedic medicine is helpful. Brain Tonics (Medhya Rasayana), special class of Rasayana agents that rejuvenate mental faculties, intellect, and memory, can be given to improve brain function.

Ayurvedic Medicinal Herbs and Useful Medicines

In Ayurveda, for Alzheimer’s and dementia, the medicinal herbs with Vatahara, Rasayana, and Medhya action are used. Along with the herbs, Panchakrama (Shirobasti, Basti, Nasya) is also used. For Nasya, Brahmi Ghrita is used. In Shirobasti, Brahmi and Himsagar Taila are used. Daily intake of turmeric powder in dose of 2-3 grams is recommended. Food which is easy to digest and nutritious and without excess spice, salt and oil is recommended.

Turmeric – Curcuma longa

Haridra (also known as Rajni, Nisha, Nishi, Haldi, Haladhi, Turmeric) consists of the dried and cured rhizomes of Curcuma longa Linn. It mainly contains essential oil and curcumin. It is bitter, and pungent in taste (Rasa), pungent after digestion (Vipaka), and is hot in effect (Virya). It is Ruksha (drying) in quality (Guna). Turmeric balances vitiated Kapha and Pitta. It is anthelmintic (Krimighna) and poison-destroying (Vishaghna). It is used in all type of skin diseases both internally and externally. As it is drying in nature, it reduces excessive phlegm in body. It detoxifies blood.

The pharmacological activities of Curcuma longa extract are reported to have significant effects on the human body. It is anti-oxidant, anti alzheimer’s, anti cancerous, anti viral, abortificient, anticonvulsant, anti hepatotoxic, anti hyper cholesterolemic, anti hyperlipemic, anti inflammatory, anti spasmodic, CNS depressant, plasma bilirubin decreaser, platelet aggregation inhibitor and weight gain inhibitor. It is beneficial for heart. Anything which is good for heart is also beneficial for brain. It has significant antioxidant action and protects against neurodegenerative diseases.  Curcumin has potent anti-amyloidogenic effects for Alzheimer‘s beta amyloidfibrils.

Curcumin is the principal curcuminoid and is responsible for the yellow color of the turmeric root. Curcumin reduced the amount of plaque deposition. It reduced oxidative damage and reversed the amyloid pathology. Epidemiologic studies show a 4.4-fold lower incidence of Alzheimer’s in Southeast Asian countries where turmeric is commonly used as a dietary spice. Other studies indicate that the non-steroidal anti-inflammatory property of turmeric is associated with a reduced risk of Alzheimer’s. Alzheimer’s symptoms characterized by inflammation and oxidation were also eased by curcumin’s powerful antioxidant and anti-inflammatory properties.

Ashwagandha – Withania somnifera Dunal

Ashwagandha / Indian ginseng / Indian winter cherry, refers to the roots of a medicinal plant Withania somnifera. It has antidepressant effect on central nervous system and stimulant effect on brain and reduces anxiety and stress.

The dried root powder has adaptogen, tonic, anti-inflammatory, immunomodulator, anti-tumour, nervine, mild sedative, analgesic, reproductive tonic, aphrodisiac and anti-anaemic properties. It is a Rasayana that gives longevity and vitality. It is prescribed for promoting health, longevity, arresting aging process, revitalizing the body in debilitated conditions, increasing immunity, treating musculoskeletal conditions and as general tonic to increase energy.

Withanamides, present in Ashwagandha has shown to scavenge free radicals generated during the initiation and progression of Alzheimer’s. Neuronal cell death triggered by amyloid plaques is also blocked by withanamides.  Withanamides A and C uniquely bind to the active motif of beta-amyloid and prevent fibril formation. Intake of Ashwagandha in dose of 500 mg/day, helps in forgetfulness.

Shankhpushpi – Convolvulus pluricaulis

Shankhpushpi / Convolvulus pluricaulis, bears conch shell-like flowers and hence it is named as Shankhpushpi (Shankha = Conch; Pushp = Flowers). It is boon for brain. It is a powerful brain stimulant.  Shankhpushpi is hypotensive, anti–thyroid and sedative. It improves mental functions and reduces stress due to traumatic, chemical or psychological reasons. Shankhpushpi is used in treatment of epilepsy, insanity, weakness of nerves and mental retardation.

Shankhpushpi is Katu (Pungent), Tikta (Bitter) and Kashaya (Astringent) in taste (Ras) and Laghu (light), Slimy and Oily in action (Guna). Its post-digestive effect (Vipak) is Madhura (Sweet). It is a Sheet Virya herbs. Sheet Virya or Cool potency herb, subdues Pitta (Bile) Vata (Wind) and increases Kapha (Mucus). Sheet Virya herb gives nourishment to body and steadiness. It supports building of body fluids.

  • Rasa (taste on tongue): Kashaya (Astringent), Katu (Pungent), Tikta (Bitter)
  • Guna (Pharmacological Action): Snigdha (Unctuous), Laghu (Light), Picchal (Slimy)
  • Virya (Action): Sita (Cooling)
  • Vipaka (transformed state after digestion): Madhura (Sweet)

Shankhpushpi is tridoshhar and balances Vata, Pitta and Kapha. Shankhpushpi reduces different types of stress, including psychological, chemical and traumatic. It has anti-anxiety, hypotensive and mental function improving property. It is a brain tonic and used to treat mental weakness, mental disorders, insanity, to improve memory.

Shankhpushpi is beneficial for neurodegenerative diseases. It has antioxidant action and improves memory.  It is employed in medical treatment of brain related ailments like dementia, OCD, phobias and insomnia. Its consumption retards memory loss and has been tried successfully in Parkinson Syndrome and Alzheimer’s disease.

The constituent convolvine is responsible for blocking M2 and M4 cholinergic muscuranic receptors. It potentiates effects of arecoline, a muscuranic memory enhancer that ameliorates cognitive defects in Alzheimer’s.  The paste made from small leaves of shankhpushpi mixed with its roots and flowers can be taken regularly.

Brahmi – Bacopa monniera Linn

Brahmi / Bacopa monnieri (often confused with its close relative Gotu kola Centella asiatica) which is also called Brahmi in Northern India), is bitter (Tikta), astringent (Kashaya) in taste (Ras), light (Laghu), unctuous (Snigdha) in qualities (Guna). It is pungent (Katu) after digestion (Vipak) and Cool in potency. Brahmi balances Vata, Pitta and Kapha Dosha. It works on seven Dhatu of body. Brahmi is especially beneficial for mind. It is a nervine tonic, sedative, rejuvenative, anticonvulsant and anti-inflammatory. In Ayurveda, it is indicated in mental weakness, anxiety, skin disorders, and fever. It is a memory vitalizer and nervine tonic.

  • Rasa (Taste on Tongue): Bitter/Titka, Astringent/Kashaya
  • Guna (Pharmacological Action): Light/Laghu, Unctuous/Snigdha
  • Virya (Action): Cooling/Sheeta
  • Vipaka (Transformed State After Digestion): Pungent/Katu
  • Dosha: Vata-Pitta and Kapha Balancing
  • Tissue/Dhatu: All Seven, Especially Plasma, Blood, Nerve

Brahmi is adaptogenic, astringent, diuretic, sedative, potent nervine tonic, anti-anxiety agent, and improves mental functions. It is used in insanity, epilepsy, bronchitis, asthma and diarrhea. Brahmi is chiefly used in mental disorders as brain tonic.

Brahmi increases GABA (Gamma Aminobutyric Acid) level in brain. GABA is an amino acid / brain chemical or neurotransmitter that sends signals from nerve cell to a specific target cell. Low level of this chemical or GABA deficiency causes stress, mood disorders, depression, insomnia, hypertension and anxiety.

Brahmi and Shankhpushpi possess properties similar to nootropic agents. They are cooling in nature and reduces excessive heat inside body, stress, and anger.

Boil ½ teaspoon brahmi in a cup of milk and drink at bedtime. It will improve memory remarkably. Add a pinch of saffron for increased benefit. This can be taken every day for a month, or take as long as yoy want.

You may also take Brahmi Ghrita in dose of 1 teaspoon, twice a day. This should be taken 5 to 10 minutes before breakfast and before dinner.

Jatamansi – Nardostachys jatamansi

Jatamansi, Balchhar, Balchir, Baluchar, Jatalasi, Jatamansi, Kanuchara, Spikenard are few names of Nardostachys jatamansi. The roots of plant are aromatic and bitter and possess stimulant and anti-spasmodic properties. Jatamansi is used in the treatment of epilepsy, hysteria, convulsive ailments, palpitation of the heart and diseases of the head. It is nervous relaxant and antispasmodic. It cools and nourishes a ‘hot’ and ‘exhausted’ nervous system; clears pitta, calms vata, reduces kapha.

Jatamansi is a nervine tonic, hypotensive, antiseptic, stomachic, carminative, tranquilizer, sedative, anti-bacterial, antispasmodic, and stimulant. It is useful in the treatment of hysteria, convulsions, vertigo, nervousness, nervous headache, excitement, epilepsy, anxiety and insomnia. No health hazards are known in conjunction with the proper administration of designated therapeutic dosages. Combination of Gotu kola, jatamansi and Tagara is used as a sedative.

Gotu kola, Mandookparni, Brahmi – Centella asiatica

Mandukparni / Centella asiatica is a Medya (nootropic) Rasayan. The leaf looks like the cerebellum and as per doctrine of signaturesgotu kola is traditionally renowned for its intellect promoting,nervous-system, soothing and general mind enhancing properties. It has various effects on central nervous system.

It is nervine and brain tonic. It has intelligence boosting properties. It enhances learning, mental performance and memory. Mandookparni is effective in reducing brain regional lipid peroxidation and protein carbonyl levels and in increasing the antioxidant status. It enhances learning and memory.  It is Tikta-Madhur (Ras), Snigdha-Laghu (Guna) and Sheet / cool in potency (Virya).

Gotu kola relaxes the central nervous system. It is useful in behavioural and developmental imbalances such as autism, Asperger’s syndrome or ADHD. Gotu kola protects against the ageing process and Alzheimer’s. It gives relief in stress, insomnia, epilepsy, emotional turbulence and pitta/vata aggravation.  Gotu kola should not be used with other sedative drugs as it can lead to synergism.

Guduchi – Tinospora cordifolia

Guduchi s also known as Gurach, Galo, Gulancha, Guduchi, Amrita,  Shindilkodi, Guruch, Guduch, Gudurchi, GULANCHA, HEART-LEAVED MOONSEED and Tinospora. It belongs to plant family Menispermaceae. It is a herbaceous vine that propogates through stem cutting.

The stem contains several active adaptogenic constituents such as tinosporone, tinosporic acid, cordifolisides A to E, syringen, the yellow alkaloid, berberine, giloin, and a glucosidal bitter principle as well as polysaccharides, including arabinogalactan polysaccharide. These active constituents are found to possess anticomplementary and immunomodulatory activities.

Guduchi contains berberine, isoquinolone alkaloid with AChE (acetylcholinesterase inhibitory) action. Berberine helps prevent oxidation damage to bio molecules of brain, reduces peptides that interfere with memory function and lowers lipids that hamper cerebral blood flow.

Guduchi arrests neuro degenerationwhich is commonly present in Alzheimer’s disease. Berberine reduces A beta levels by modulating APP (amyloid precursors) processing in human neuroglioma cells without toxicity. It is medhya rasayana used in degenerative disorders.

Ginkgo biloba

Ginkgo prevents degeneration of sensory organs and promotes memory. It slows dementia resulting from hardening of cerebral arteries.

Ginkgo biloba extract are made from the leaves of the tree. Ginkgo leaf extracts are used in brain disorders such as dementia, disturbance in concentration, depressive emotional conditions, dizziness, tinnitus and headache. The extract has beneficial effects on the circulatory system especially in geriatric patients.

Ginkgo is available as capsules, which contains extracts of Ginkgo Biloba. The capsules can be taken in dose of 1-2 capsules daily or as directed by health care professional.

Daily intake of Ginkgo extract in dose of 240 mg helps to prevents dementia or Alzheimer’s disease.

Guggul

Guggul is gum resin (Niryas) of the Commiphora mukul tree. The principle action of Guggulu as mentioned in Ayurveda are Tridosha Shamaka, Vedanasthapana, Lekhana, Shulahara And Shothahara. It is anti-inflammatory, hypolipedemic, antiseptic, antibacterial, astringent, antispasmodic and antifertility.

Guggulu is highly effective in the treatment of Vata-Vikar and inflammatory conditions. The gum resin contains guggul sterons Z and E, guggul sterols I-V, two diterpenoids- a terpene hydrocarbon named cembreneA and a diterpene alcohol- mukulol, a-camphrone and cembrene, long chain aliphatic tetrols- octadecan-1,2,3,4-tetrol, eicosan-1,2,3,4-tetrol and nonadecan-1,2,3,4-tetrol. Major components from essential oil of gum resin are myrcene and dimyrcene.

It is effective in reducing synthesis of cholesterol in liver. It reduces serum triglycerides, LDL (bad) cholesterol and increases HDL. It can reduce 14-27 percent blood cholesterol and triglycerides by 22-30 percent. Guggulu increases metabolism of LDL.

Guggul removes toxins from body. It also works as a carrier for other drugs. It is used in Ayurveda for treatment of arthritis, rheumatism, gout, lumbago, disorders of the nervous, respiratory, digestive and circulatory systems. It has anti-inflammatory with strong purifying and rejuvenating properties.

Study demonstrated that gugulipid has a significant protective effect against the streptozotocin-induced memory deficit model of dementia, the effect can be attributed to its cholesterol-lowering, antioxidant, and anti-acetylcholine esterase activity. These observations suggest gugulipid as a potential anti-dementia drug.

Classical Ayurvedic texts recommends not to take guggul as a single drug but along with other herbs in combination.

Coconut Water

Trans-zeatin is the first naturally-occurring cytokinin identified from a plant source by Letham. Trans-Zeatin belongs to the family of plant-growth hormones called cytokinins and was discovered in immature corn kernels from the genus Zea. It promotes growth of lateral buds and when sprayed on meristems stimulates cell division to produce bushier plants.

Recent studies showed that trans-zeatin can be a potential drug to treat neural diseases. Some researchers found that trans-zeatin actually possesses an inhibitory effect on acetylcholinesterase and it can be used to treat Alzheimer’s disease or related neural dysfunctions, such as dementia.

Acetylcholinesterase degrades the neural compounds that mediate neural transmission, and thus by blocking its action, synaptic transmission can be improved. Another recent study also found that transzeatin can prevent amyloid β-protein formation.  Another recent study also found that transzeatin can prevent amyloid β-protein formation, which has a causal role in the development and progress of Alzheimer’s disease.

Ayurvedic Medicines for Improving brain function

  • Brahmi Ghrita
  • Dimagh Pushtak Rasayan
  • Geriforte
  • Manasamitra Vatakam
  • Mentat
  • Panchagavya Ghrita
  • Saraswat Churna
  • Saraswatarishta
  • Shankhpushpi Ghrita
  • Shankhpushpi Syrup
  • Vachadi Churna

Alzheimer’s Dietary Tips

It is recommended to avoid intake of aluminum. Diet rich in fruits, vegetables, olive oil, legumes, cereals and fish provide a lower risk of developing Alzheimer’s disease.

Turmeric and Coconut water can be included into diet for better health.

Omega-3 fatty acid supplements slow cognitive decline in some patients with very mild Alzheimer’s disease.

Red grapes may help neuro-degenerative disorders like Alzheimer’s disease, cognitive impairment and memory loss.

Fruit and vegetable juices reduce the risk of Alzheimer’s. But the juice should be fresh and free from artifical sweetners, colourand preservatives. They should not contain added sugar.

Avoid diet containing excessive intake of sugar, refined carbohydrates (with high glycemic index), and animal products (with high content of saturated fats).

Increase intake unrefined seeds (cereals, legumes, and oleaginous seeds), vegetables (with high fibrous content, vitamins, polyphenols, and other antioxidant substances [e.g., phytoestrogens]), and food rich in omega-3 fatty acids.

Improve general or total well-being.  By including mental exercises (memory games, reading, card games) and meditation.

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