Unwanted-21 Hormonal Contraceptive Pills

Unwanted 21 is a daily regular oral hormonal contraceptive pill used to prevent pregnancy. It is available in a pack of 21 pills. It does not allow pregnancy by preventing ovulation, implantation and making cervical secretions thick. Unwanted-21 is supposed to be 99% effective when taken correctly.

Here is given more about this medicine, such as benefits, indication/therapeutic uses, composition and dosage.

  1. Brand: Mankind
  2. Category: Hormonal Combined Contraceptive
  3. Contains: Progestin and estrogen
  4. Pack: 21 tabs
  5. Price: Rs 58. 00 for a cycle

Ingredients of Unwanted-21

Unwanted-21 Combination hormonal contraceptive pills:

Each tablet contains

  1. Levonorgestrel 0. 15 mg
  2. Ethinyl estradiol 0. 03mg.

Levonorgestrel is synthetic progestogen with chemical formula 18, 19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl- 17-hydroxy-, (17α)-, (-)-,. Ethinyl estradiol is synthetic estrogen with chemical formula 19-Norpregna-1,3, 5(10)-trien-20-yne-3, 17-diol, (17α)-.

The combination of progestogen and estrogen suppress gonadotropins. It inhibits ovulation, makes changes in cervical mucus and endometrium.

Mechanism of Action

  1. It is a combined hormonal contraceptive.
  2. It inhibits ovulation.
  3. It produce alterations in the genital tract, including changes in the cervical mucus, rendering it unfavorable for sperm penetration.
  4. It changes the endometrium producing an unfavorable environment for fertilization.
  5. Advantages of Unwanted-21
  6. It is highly effective for pregnancy prevention.
  7. It decreases menstrual flow and cramps.
  8. It regulates menstrual cycles.
  9. It protects against ovarian and endometrial cancer.
  10. It decreases benign breast lumps.

Disadvantages of Unwanted-21

  1. It contains progestogen. Some progestogens may elevate LDL levels and may render the control of hyperlipidemias more difficult.
  2. Woman suffering from lipoprotein metabolism taking estrogen-containing preparations, are at risk of significant elevations of plasma triglycerides leading to pancreatitis.
  3. It may cause some degree of fluid retention, nausea and dizziness, Breast tenderness, Intermittent Bleeding, headaches and Weight gain.
  4. It may decrease glucose tolerance.
  5. It may decrease quantity and quality of breast milk.
  6. Important Therapeutic Uses of Unwanted-21
  7. It is used to prevent pregnancy.

Dosage of Unwanted-21

  1. On first day of menstrual cycle, take 1 tablet daily for 21 consecutive days.
  2. Then for 7 days, you have to take no pill.
  3. On 8th day, start a new pack and take for next 21 days.
  4. Adverse Reactions / Side-effects
  5. An increased risk of the following serious adverse reactions has been associated with the use of oral contraceptives:
  6. Thrombophlebitis
  7. Arterial thromboembolism
  8. Pulmonary embolism
  9. Myocardial infarction
  10. Cerebral hemorrhage
  11. Cerebral thrombosis
  12. Hypertension
  13. Gallbladder disease
  14. Hepatic adenomas or benign liver tumor
  15. There is evidence of an association between the following conditions and the use of oral contraceptives:
  16. Mesenteric thrombosis
  17. Retinal thrombosis
  18. The following adverse reactions have been reported in patients receiving oral contraceptives.
  19. Nausea
  20. Vomiting
  21. Gastrointestinal symptoms (such as abdominal cramps and bloating)
  22. Breakthrough bleeding
  23. Spotting
  24. Change in menstrual flow
  25. Amenorrhea
  26. Temporary infertility after discontinuation of treatment
  27. Edema/fluid retention
  28. Melasma/chloasma which may persist
  29. Changes in Breast, tenderness, enlargement, and secretion
  30. Change in weight or appetite (increase or decrease)
  31. Change in cervical ectropion and secretion
  32. Possible diminution in lactation when given immediately postpartum
  33. Cholestatic jaundice
  34. Migraine headache
  35. Rash (allergic)
  36. Mood changes, including depression
  37. Vaginitis, including candidiasis
  38. Intolerance to contact lenses
  39. Decrease in serum folate levels
  40. Exacerbation of porphyria
  41. Exacerbation of chorea
  42. Aggravation of varicose veins
  43. Anaphylactic/anaphylactoid reactions, including urticaria, angioedema, and severe reactions with respiratory and circulatory symptoms
  44. There may be some delay in becoming pregnant after stopping oral contraceptives.
  45. It does not appear to be any increase in birth defects in newborn babies when pregnancy occurs soon after stopping the pill.


  1. Thrombophlebitis or thromboembolic disorders, past history of deep vein thrombophlebitis or thromboembolic disorders
  2. Cerebrovascular or coronary artery disease (current or history)
  3. Valvular heart disease with thrombogenic complications
  4. Uncontrolled hypertension
  5. Diabetes with vascular involvement
  6. Headaches with focal neurological symptoms
  7. Major surgery with prolonged immobilization
  8. Known or suspected carcinoma of the breast or personal history of breast cancer
  9. Hepatic adenomas or carcinomas, or active liver disease
  10. Carcinoma of the endometrium or other known or suspected estrogen-dependent neoplasia
  11. Undiagnosed abnormal genital bleeding
  12. Cholestatic jaundice of pregnancy or jaundice with prior pill use
  13. Known or suspected pregnancy
  14. Breast feeding
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