Unwanted 21 is a daily regular oral hormonal contraceptive pill used to
prevent pregnancy. It is available in a pack of 21 pills. It does not allow
pregnancy by preventing ovulation, implantation and making cervical secretions
thick. Unwanted-21 is supposed to be 99% effective when taken correctly.
Here is given more about this medicine, such as benefits,
indication/therapeutic uses, composition and dosage.
- Brand: Mankind
- Category: Hormonal Combined Contraceptive
- Contains: Progestin and estrogen
- Pack: 21 tabs
- Price: Rs 58. 00 for a cycle
Ingredients of Unwanted-21
Unwanted-21 Combination hormonal contraceptive pills:
Each tablet contains
- Levonorgestrel 0. 15 mg
- Ethinyl estradiol 0. 03mg.
Levonorgestrel is synthetic progestogen with chemical formula 18,
19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl- 17-hydroxy-, (17α)-, (-)-,. Ethinyl
estradiol is synthetic estrogen with chemical formula 19-Norpregna-1,3,
5(10)-trien-20-yne-3, 17-diol, (17α)-.
The combination of progestogen and estrogen suppress gonadotropins. It
inhibits ovulation, makes changes in cervical mucus and endometrium.
Mechanism of Action
- It is a combined hormonal contraceptive.
- It inhibits ovulation.
- It produce alterations in the genital tract, including changes in the
cervical mucus, rendering it unfavorable for sperm penetration.
- It changes the endometrium producing an unfavorable environment for
- Advantages of Unwanted-21
- It is highly effective for pregnancy prevention.
- It decreases menstrual flow and cramps.
- It regulates menstrual cycles.
- It protects against ovarian and endometrial cancer.
- It decreases benign breast lumps.
Disadvantages of Unwanted-21
- It contains progestogen. Some progestogens may elevate LDL levels and may
render the control of hyperlipidemias more difficult.
- Woman suffering from lipoprotein metabolism taking estrogen-containing
preparations, are at risk of significant elevations of plasma triglycerides
leading to pancreatitis.
- It may cause some degree of fluid retention, nausea and dizziness, Breast
tenderness, Intermittent Bleeding, headaches and Weight gain.
- It may decrease glucose tolerance.
- It may decrease quantity and quality of breast milk.
- Important Therapeutic Uses of Unwanted-21
- It is used to prevent pregnancy.
Dosage of Unwanted-21
- On first day of menstrual cycle, take 1 tablet daily for 21 consecutive
- Then for 7 days, you have to take no pill.
- On 8th day, start a new pack and take for next 21 days.
- Adverse Reactions / Side-effects
- An increased risk of the following serious adverse reactions has been
associated with the use of oral contraceptives:
- Arterial thromboembolism
- Pulmonary embolism
- Myocardial infarction
- Cerebral hemorrhage
- Cerebral thrombosis
- Gallbladder disease
- Hepatic adenomas or benign liver tumor
- There is evidence of an association between the following conditions and the
use of oral contraceptives:
- Mesenteric thrombosis
- Retinal thrombosis
- The following adverse reactions have been reported in patients receiving
- Gastrointestinal symptoms (such as abdominal cramps and bloating)
- Breakthrough bleeding
- Change in menstrual flow
- Temporary infertility after discontinuation of treatment
- Edema/fluid retention
- Melasma/chloasma which may persist
- Changes in Breast, tenderness, enlargement, and secretion
- Change in weight or appetite (increase or decrease)
- Change in cervical ectropion and secretion
- Possible diminution in lactation when given immediately postpartum
- Cholestatic jaundice
- Migraine headache
- Rash (allergic)
- Mood changes, including depression
- Vaginitis, including candidiasis
- Intolerance to contact lenses
- Decrease in serum folate levels
- Exacerbation of porphyria
- Exacerbation of chorea
- Aggravation of varicose veins
- Anaphylactic/anaphylactoid reactions, including urticaria, angioedema, and
severe reactions with respiratory and circulatory symptoms
- There may be some delay in becoming pregnant after stopping oral
- It does not appear to be any increase in birth defects in newborn babies
when pregnancy occurs soon after stopping the pill.
- Thrombophlebitis or thromboembolic disorders, past history of deep vein
thrombophlebitis or thromboembolic disorders
- Cerebrovascular or coronary artery disease (current or history)
- Valvular heart disease with thrombogenic complications
- Uncontrolled hypertension
- Diabetes with vascular involvement
- Headaches with focal neurological symptoms
- Major surgery with prolonged immobilization
- Known or suspected carcinoma of the breast or personal history of breast
- Hepatic adenomas or carcinomas, or active liver disease
- Carcinoma of the endometrium or other known or suspected estrogen-dependent
- Undiagnosed abnormal genital bleeding
- Cholestatic jaundice of pregnancy or jaundice with prior pill use
- Known or suspected pregnancy
- Breast feeding