Combiflam Detail Information

Combiflam is brand name of an allopathic over the counter OTC medicine used to treat fever, flu, cold, pain in body, swelling, backache, joint swelling, rheumatic disorders etc. It is combination of ibuprofen and paracetamol. It is available as tablets and syrup.

Combiflam is a Nonsteroidal Anti-Inflammatory Drug (NSAID). NSAIDs medicines reduce inflammation but are not related to steroids. Such medicines work by reducing the production of prostaglandins. Prostaglandins are chemicals that promote inflammation, pain, and fever.


ibuprofen 400mg + paracetamol 325mg

Properties of Combiflam

  • Analgesics: Gives relief in pain.
  • Antipyretic/antifebrile/febrifuge: Effective against fever.
  • Anti-inflammatory: Reducing inflammation by acting on body mechanisms.
  • Anti-platelet: reduces platelets.

Uses of Combiflam

Combiflam is used to get relief from fever, cold and flu symptoms, mild to moderate pain associated with migraine, headache, backache, dental pain, menstrual pain. It is also used in pain and inflammation associated with musculoskeletal and joint disorders.

  • This product is especially suitable for pain which requires stronger pain relieving action.
  • Fever, cold, flu, sore throat
  • Musculoskeletal disorders (injuries or pain in the body's joints, ligaments, muscles, nerves, tendons, and structures that support limbs, neck and back)
  • Arthritic pain, rheumatism, gout
  • Headaches, Migraines, Dental pain, Neuralgia
  • Injuries
  • Painful menstruation
  • After delivery

Dosage of Combiflam

  • Take the lowest effective dose for the shortest time.
  • Adult:(Ibuprofen 400 mg + Paracetamol 325/500 mg) 1 tab 3 times daily with water. There should be gap of six hours between dosages.
  • Child:(Ibuprofen 100mg + Paracetamol 125mg) 1 dose two-three times a day or as required. Give only after consulting doctor.


  • This medicine should not be taken in
  • Active peptic ulcer
  • History of hypersensitivity/allergic reactions to other NSAIDs, aspirin
  • Gastrointestinal bleeding
  • Bleeding in stomach
  • Kidney failure, liver failure
  • Increased tendency to bleed
  • Low platelets
  • and in infants
  • Do not use in pregnancy.
  • The patients with bronchial asthma, kidney and liver disorders, bleeding disorders, high blood pressure, patients on anticoagulants, aspirin/NSAIDs induced allergy should take it cautiously.

Side-effects of Combiflam

  • Adverse effects include upper gastrointestinal mucosal damage, dyspepsia, nausea, vomiting, gastrointestinal bleeding, hypersensitivity and rarely renal failure and heart failure.
  • The most common adverse effects of this drug are gastritis, Nausea or vomiting, cramps, diarrhea, acidity, gas, ringing in ear, rash peptic ulceration, and depression of renal function.
  • Skin allergy, rash, urticaria is also seen in few patients.
  • It causes thrombocytopenia which means deficiency of platelets in the blood. This causes bleeding into the tissues, bruising, and slow blood clotting after injury.
  • It can aggravate lung problems for those having respiratory disorders such as asthma.
  • Other side effects
  • Drowsiness, vision disturbances, disorientation, Shortness of breath or wheezing, Chest pain or tightness in the chest, Swelling in your ankles or legs, and redness of skin.

Drug Interactions

  • It reduces the effects of furosemide and thiazides.
  • Its absorption is reduced by Pethidine and propanthelene.
  • It reduces the effects of anti-hypertensives (control high blood pressure).
  • It increases effect of anticoagulants.
  • It interacts with blood clotting medicines, Blood thinning drugs, Steroids and cholesterol lowering medicines.
blog comments powered by Disqus