Short information on Avomine 25 mg tablets

Avomine is a medicine to prevent and treat motion sickness, vomiting and treating short term sleep difficulty. Each tablet of Avomine contains Promethazine theoclate (25 mg). Promethazine can also be used to treat sickness, vertigo (loss of balance or dizziness) and problems affecting the ear. Because promethazine causes drowsiness, it is also occasionally used to treat insomnia (difficulty sleeping). This belongs to the group of medicines known as antihistamines. For motion sickness, this should be taken 1-2 hours before the scheduled journy.

Composition of Avomine

  • Promethazine theoclate (25 mg)

Uses of Avomine

  • Prevention and treatment of motion sickness/travel sickness
  • Allergies, sickness, vertigo (loss of balance or co-ordination) and other problems affecting the ear that affect balance.

Dosage of Avomine

Preventing Travel sickness

  • Adults For Long journeys: 1 tablet each night at bedtime commencing on the night before travelling.
  • Short journeys: 1 tablet to be taken 1 to 2 hours before the journey commences.
  • Nausea: 1 once to four times daily.

For treating travel sickness

  • One tablet, followed by a second tablet the same evening and a third tablet on the following evening. Prompt treatment is important.
  • Additional tablets may safely be taken for prophylaxis or when they appear to be needed but it will seldom be necessary to give more than four tablets in 24 hours or to repeat a dose in less than 8 hours.


  • 5 - 10 years: one half the corresponding adult dosage.
  • Over 10 years: corresponding adult dosage.


  • The medicine is contraindicated in Coma, CNS depression.
  • This medicine should not be used in children under 2 years of age.
  • Its safety in pregnancy (category C) and lactation is not established.


Gastrointestinal. Dry mouth, epigastric distress, loss of appetite, nausea, vomiting, diarrhoea, constipation.

Nervous system. Sedation, restlessness, dizziness, lassitude, incoordination, fatigue, Blurred vision

Less common reactions

Cardiovascular, Tachycardia, bradycardia, faintness, palpitations, hypotension, arrhythmias.

Dermatological. Contact dermatitis (topical), photosensitisation, urticaria, angioneurotic, oedema.

Leucopenia, agranulocytosis, aplastic anaemia, thrombocytopenic purpura., Jaundice.

Extrapyramidal symptoms

Nervous system. Tinnitus, euphoria, nervousness, insomnia, convulsive seizures, oculogyric

crises, excitation, catatonic-like states, hysteria, extrapyramidal symptoms, tardive dyskinesia.

Respiratory Marked irregular respiration, Anaphylaxis, headaches, nightmares, urinary retention.

Serious or life-threatening reactions

Agranulocytosis. Care is needed in the intramuscular administration of promethazine to children. A severe neurological reaction resulting in coma is possible.

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